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The photothermal properties of a nanomaterial are of tremendous, increasing interest in biomedical fields due to their excellent optical response and controllable photothermal effect by external light energy. In previous decades, most biomedical applications using photothermal nanomaterials have focused on photothermal effects in cancer treatment. With the increasing understanding of this unique property of nanomaterials, we should emphasize the potential of these nanomaterials for clinical translation by exploring photothermal effect-based theranostics in cancer. This chapter briefly summarizes recent advances in the applications of photothermal nanomaterials for oncological hyperthermia, particularly a discussion on the advantages, challenges, and safety concerns for clinical application.

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