DNA Damage, DNA Repair and Disease: Volume 2
The DNA of all organisms is constantly being damaged by endogenous and exogenous sources. Oxygen metabolism generates reactive species that can damage DNA, proteins and other organic compounds in living cells. Exogenous sources include ionizing and ultraviolet radiations, carcinogenic compounds and environmental toxins among others. The discovery of multiple DNA lesions and DNA repair mechanisms showed the involvement of DNA damage and DNA repair in the pathogenesis of many human diseases, most notably cancer. These books provide a comprehensive overview of the interdisciplinary area of DNA damage and DNA repair, and their relevance to disease pathology. Edited by recognised leaders in the field, this two-volume set is an appealing resource to a variety of readers including chemists, chemical biologists, geneticists, cancer researchers and drug discovery scientists.
DNA Damage, DNA Repair and Disease: Volume 2, The Royal Society of Chemistry, 2020.
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Chapter 16: Mechanisms and Maps of Nucleotide Excision Repairp1-23ByC. M. Vaughn;C. M. VaughnDepartment of Biochemistry and Biophysics120 Mason Farm Rd, Campus Box 7260Chapel HillNC 27599USA[email protected]Search for other works by this author on:A. SancarA. SancarDepartment of Biochemistry and Biophysics120 Mason Farm Rd, Campus Box 7260Chapel HillNC 27599USA[email protected]Search for other works by this author on:
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Chapter 17: Emerging Concepts on the Early Steps of Base Excision Repair Pathway with a Focus on Gene Expressionp24-47ByG. Antoniali;G. AntonialiLaboratory of Molecular Biology and DNA repair, Department of Medicine (DAME), University of UdineUdineItaly[email protected]Search for other works by this author on:M. C. Malfatti;M. C. MalfattiLaboratory of Molecular Biology and DNA repair, Department of Medicine (DAME), University of UdineUdineItaly[email protected]Search for other works by this author on:G. TellG. TellLaboratory of Molecular Biology and DNA repair, Department of Medicine (DAME), University of UdineUdineItaly[email protected]Search for other works by this author on:
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Chapter 18: Base Excision Repair in Plants: Variations on a Themep48-74ByDolores Córdoba-Cañero;Dolores Córdoba-CañeroDepartment of Genetics, University of CórdobaSpainReina Sofía University HospitalSpainSearch for other works by this author on:Rafael R. Ariza;Rafael R. ArizaDepartment of Genetics, University of CórdobaSpainReina Sofía University HospitalSpainSearch for other works by this author on:Teresa Roldán-ArjonaTeresa Roldán-ArjonaDepartment of Genetics, University of CórdobaSpainReina Sofía University HospitalSpainSearch for other works by this author on:
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Chapter 19: OGG1 at the Crossroads of Inflammation and DNA Base Excision Repairp75-103ByI. Boldogh;I. BoldoghDepartment of Microbiology and Immunology, University of Texas Medical BranchGalvestonTexas77555USA[email protected]Department of Medicine, School of Medicine, University of Texas Medical BranchGalvestonTexas77555USASearch for other works by this author on:L. Pan;L. PanDepartment of Microbiology and Immunology, University of Texas Medical BranchGalvestonTexas77555USA[email protected]Search for other works by this author on:S. Vlahopoulos;S. VlahopoulosHoremeio Research Laboratory, First Department of Pediatrics, National and Kapodistrian University of Athens11527 AthensGreeceSearch for other works by this author on:X. Zheng;X. ZhengDepartment of Microbiology and Immunology, University of Texas Medical BranchGalvestonTexas77555USA[email protected]Key Laboratory of Molecular Epigenetics of Ministry of Education, School of Life Science, Northeast Normal UniversityChangchunJilin 130024ChinaSearch for other works by this author on:K. Wang;K. WangDepartment of Microbiology and Immunology, University of Texas Medical BranchGalvestonTexas77555USA[email protected]Key Laboratory of Molecular Epigenetics of Ministry of Education, School of Life Science, Northeast Normal UniversityChangchunJilin 130024ChinaSearch for other works by this author on:T. K. Hazra;T. K. HazraDepartment of Medicine, School of Medicine, University of Texas Medical BranchGalvestonTexas77555USASearch for other works by this author on:M. L. Hegde;M. L. HegdeDepartment of Radiation Oncology, Houston Methodist Research InstituteHoustonTXUSASearch for other works by this author on:A. Bacsi;A. BacsiDepartment of Immunology, Faculty of Medicine, University of DebrecenDebrecenHungary, H-4032Search for other works by this author on:Z. Radak;Z. RadakResearch Institute of Sport Science, Semmelweis UniversityBudapestHungarySearch for other works by this author on:A. R. Brasier;A. R. BrasierInstitute for Clinical and Translational Research, University of Wisconsin-Madison School of Medicine and Public HealthMadisonWisconsin 53705USASearch for other works by this author on:X. BaX. BaKey Laboratory of Molecular Epigenetics of Ministry of Education, School of Life Science, Northeast Normal UniversityChangchunJilin 130024ChinaSearch for other works by this author on:
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Chapter 20: Fidelity Mechanisms of DNA Polymerase Betap104-128ByJ. B. SweasyJ. B. SweasySearch for other works by this author on:
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Chapter 21: DNA Damage Leads to Neurodegeneration via Mitochondrial Dysfunctionp129-151ByB. A. Baptiste;B. A. BaptisteLaboratory of Molecular Gerontology, National Institute on Aging251 Bayview Blvd.BaltimoreMD 21224USA[email protected]Search for other works by this author on:P. Sykora;P. SykoraAmelia Technologies1121 5th Street NWWashingtonDC 20001USASearch for other works by this author on:M. Babbar;M. BabbarLaboratory of Molecular Gerontology, National Institute on Aging251 Bayview Blvd.BaltimoreMD 21224USA[email protected]Search for other works by this author on:S. L. Seagrave;S. L. SeagraveAmelia Technologies1121 5th Street NWWashingtonDC 20001USASearch for other works by this author on:D. L. Croteau;D. L. CroteauLaboratory of Molecular Gerontology, National Institute on Aging251 Bayview Blvd.BaltimoreMD 21224USA[email protected]Search for other works by this author on:V. A. BohrV. A. BohrLaboratory of Molecular Gerontology, National Institute on Aging251 Bayview Blvd.BaltimoreMD 21224USA[email protected]Search for other works by this author on:
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Chapter 22: Emerging Roles of Sirtuins in Chromatin Regulation and DNA Repair via their NAD+-dependent Activitiesp152-163ByY. Rodriguez;Y. RodriguezGenome Integrity and Structural Biology Laboratory, National Institutes of Health, NIEHSResearch Triangle ParkNorth Carolina 27709USA[email protected]Search for other works by this author on:S. H. WilsonS. H. WilsonGenome Integrity and Structural Biology Laboratory, National Institutes of Health, NIEHSResearch Triangle ParkNorth Carolina 27709USA[email protected]Search for other works by this author on:
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Chapter 23: Unique Roles of Human Translesion Synthesis DNA Polymerase ηp164-189ByP. P. Ghodke;P. P. GhodkeDepartment of Biochemistry, Vanderbilt University School of Medicine638B Robinson Research Building, 2200 Pierce AvenueNashvilleTennessee 37232-0146USA[email protected]Search for other works by this author on:F. P. GuengerichF. P. GuengerichDepartment of Biochemistry, Vanderbilt University School of Medicine638B Robinson Research Building, 2200 Pierce AvenueNashvilleTennessee 37232-0146USA[email protected]Search for other works by this author on:
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Chapter 24: Replicative and Transcriptional Bypass of Alkylated DNA Lesions in Human Cellsp190-213ByY. Tan;Y. TanEnvironmental Toxicology Graduate Program, University of CaliforniaRiversideCA 92521-0403USA[email protected]Search for other works by this author on:S. Guo;S. GuoEnvironmental Toxicology Graduate Program, University of CaliforniaRiversideCA 92521-0403USA[email protected]Search for other works by this author on:Y. WangY. WangEnvironmental Toxicology Graduate Program, University of CaliforniaRiversideCA 92521-0403USA[email protected]Department of Chemistry, University of CaliforniaRiversideCA 92521USASearch for other works by this author on:
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Chapter 25: Mutational Spectra Provide Insight into the Mechanisms Bridging DNA Damage to Genetic Diseasep214-253ByB. I. Fedeles;B. I. FedelesDepartments of Chemistry, Biological Engineering and Center for Environmental Health Sciences, Massachusetts Institute of TechnologyCambridgeMAUSA[email protected][email protected]Search for other works by this author on:J. M. EssigmannJ. M. EssigmannDepartments of Chemistry, Biological Engineering and Center for Environmental Health Sciences, Massachusetts Institute of TechnologyCambridgeMAUSA[email protected][email protected]Search for other works by this author on:
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Chapter 26: Evolving DNA Repair Targets for Cancer Therapyp254-285ByM. T. Sadiq;M. T. SadiqDepartment of Oncology, Nottingham University HospitalsCity Hospital CampusNottingham NG5 1PBUKSearch for other works by this author on:S. MadhusudanS. MadhusudanDivision of Cancer and Stem Cells, School of Medicine, University of Nottingham Biodiscovery InstituteNottingham NG7 2RDUK[email protected]Search for other works by this author on:
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Chapter 27: Basic, Translational and Clinical Relevance of the DNA Repair and Redox Signaling Protein APE1 in Human Diseasesp286-318ByS. Gampala;S. GampalaHerman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine1044 W. WalnutIndianapolisIN 46202USA[email protected]Search for other works by this author on:R. A. Caston;R. A. CastonHerman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine1044 W. WalnutIndianapolisIN 46202USA[email protected]Search for other works by this author on:M. L. Fishel;M. L. FishelHerman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine1044 W. WalnutIndianapolisIN 46202USA[email protected]Department of Pharmacology and Toxicology, Indiana University School of MedicineIndianapolisIN 46202USAIndiana University Simon Cancer Center, Indiana University School of MedicineIndianapolisIN 46202USASearch for other works by this author on:M. R. KelleyM. R. KelleyHerman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine1044 W. WalnutIndianapolisIN 46202USA[email protected]Department of Pharmacology and Toxicology, Indiana University School of MedicineIndianapolisIN 46202USADepartment of Biochemistry and Molecular Biology, Indiana University School of MedicineIndianapolisIN 46202USAIndiana University Simon Cancer Center, Indiana University School of MedicineIndianapolisIN 46202USASearch for other works by this author on:
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Chapter 28: The Role of PARP and the Therapeutic Potential of PARP Inhibitors in Cancerp319-360ByN. J. CurtinN. J. CurtinTranslational and Clinical Research Institute, Newcastle University Centre for Cancer, Faculty of Medical Sciences, Medical School, Newcastle UniversityNewcastle upon Tyne NE2 4HHUK[email protected]Search for other works by this author on:
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Chapter 29: Translating DNA Adduct Knowledge to Human Prevention Trialsp361-387ByJ. W. Smith;J. W. SmithDepartment of Environmental Health and Engineering, Bloomberg School of Public Health, Johns Hopkins UniversityBaltimore, MD 21205USA[email protected]Search for other works by this author on:J. D. GroopmanJ. D. GroopmanDepartment of Environmental Health and Engineering, Bloomberg School of Public Health, Johns Hopkins UniversityBaltimore, MD 21205USA[email protected]Search for other works by this author on:
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Chapter 30: DNA Damage and the Maintenance of Nuclear Genome Integrity in Aging and Associated Phenotypesp388-425ByD. M. Wilson IIID. M. Wilson IIIHasselt University, Biomedical Research Institute3590 Diepenbeek & Boost Scientific3550 Heusden-ZolderBelgium[email protected]Search for other works by this author on:
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Chapter 31: Gamma- and Ion-beam DNA Radiation Damage: Theory and Experimentp426-457ByD. Becker;D. BeckerDepartment of Chemistry, Oakland University146 Library DriveRochesterMI – 48309USA[email protected][email protected]Search for other works by this author on:A. Kumar;A. KumarDepartment of Chemistry, Oakland University146 Library DriveRochesterMI – 48309USA[email protected][email protected]Search for other works by this author on:A. Adhikary;A. AdhikaryDepartment of Chemistry, Oakland University146 Library DriveRochesterMI – 48309USA[email protected][email protected]Search for other works by this author on:M. D. SevillaM. D. SevillaDepartment of Chemistry, Oakland University146 Library DriveRochesterMI – 48309USA[email protected][email protected]Search for other works by this author on:
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