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Chemical Biology
DNA Damage, DNA Repair and Disease: Volume 2
Edited by
Miral Dizdaroglu;
Miral Dizdaroglu
National Institute of Standards and Technology
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Miral Dizdaroglu;
Miral Dizdaroglu
National Institute of Standards and Technology
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R Stephen LLoyd
R Stephen LLoyd
Oregon Health
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Hardback ISBN:
978-1-83916-251-0
PDF ISBN:
978-1-83916-254-1
EPUB ISBN:
978-1-83916-256-5
Special Collection:
2020 ebook collection
Series:
Chemical Biology
No. of Pages:
480
Publication date:
11 Nov 2020
Book Chapter
Chapter 26: Evolving DNA Repair Targets for Cancer Therapy
By
M. T. Sadiq
;
M. T. Sadiq
Department of Oncology, Nottingham University Hospitals
City Hospital Campus
Nottingham NG5 1PB
UK
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S. Madhusudan
S. Madhusudan
Division of Cancer and Stem Cells, School of Medicine, University of Nottingham Biodiscovery Institute
Nottingham NG7 2RD
UK
Srinivasan.Madhusudan@nottingham.ac.uk
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Published:11 Nov 2020
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Special Collection: 2020 ebook collectionSeries: Chemical Biology
Citation
M. T. Sadiq and S. Madhusudan, in DNA Damage, DNA Repair and Disease: Volume 2, ed. M. Dizdaroglu, R. S. Lloyd, M. Dizdaroglu, and R. S. LLoyd, The Royal Society of Chemistry, 2020, ch. 26, pp. 254-285.
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The landscape of cancer therapeutics is rapidly evolving with the introduction of novel treatments, such as immunotherapy. DNA damage repair pathways have been implicated in the emergence of and prognostication of cancer. However, extensive study has led to the creation of a host of agents moderating the DNA damage response to optimise anticancer activity.
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