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Bioreactors are designed spaces where biological reactions take place and have gained interest amongst biological researchers for their ability to effectively remove pollutants from various wastewaters. In addition to the biological aspect, engineering or designing aspects are also associated with bioreactors and this has been a topic of discussion among bioengineers due to the challenges associated with their operation. The advancement of technology and the ever-increasing application of bioreactors has amplified research associated with the design and operation of bioreactors. This in turn has opened the door to extending the application of bioreactors to various areas which were previously unknown. A bioreactor is an engineered space that provides a suitable/optimal biological environment for all the required reactions to occur adequately. Thus, the present chapter discusses types and modelling of bioreactors, and scale-up and scale-down of bioreactor applications. Limitations in the commercialization of bioreactors are also addressed. Lastly, future aspects are elaborated in detail considering the recent trends and the present scenario.

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