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Drug Discovery
Chemical Linkers in Antibody–Drug Conjugates (ADCs)
Edited by
Floris van Delft;
Floris van Delft
Synaffix BV, Netherlands
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John M. Lambert
John M. Lambert
Immunogen Inc., USA
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Hardback ISBN:
978-1-83916-263-3
PDF ISBN:
978-1-83916-515-3
EPUB ISBN:
978-1-83916-516-0
Special Collection:
2021 ebook collection
Series:
Drug Discovery
No. of Pages:
460
Publication date:
15 Dec 2021
Book Chapter
Chapter 7: ADC Linkers Strategies for the Release of Alcohol-containing Payloads
By
Jared T. Miller
;
Jared T. Miller
Binghamton University, School of Pharmacy and Pharmaceutical Sciences
PO Box 6000
Binghamton
NY 13902-6000
USA
ntumey@binghamton.edu
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L. Nathan Tumey
L. Nathan Tumey
Binghamton University, School of Pharmacy and Pharmaceutical Sciences
PO Box 6000
Binghamton
NY 13902-6000
USA
ntumey@binghamton.edu
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Published:15 Dec 2021
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Special Collection: 2021 ebook collectionSeries: Drug Discovery
Citation
J. T. Miller and L. N. Tumey, in Chemical Linkers in Antibody–Drug Conjugates (ADCs), ed. F. van Delft and J. M. Lambert, The Royal Society of Chemistry, 2021, ch. 7, pp. 232-262.
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In spite of tremendous advances in the design of ADC linkers, there continue to be limited options for the release of payloads that do not contain a free amino group. Herein, we review a variety of cleavable linker strategies that have been employed for both phenolic and aliphatic alcohols. We highlight the advantages and shortcomings of each approach, particularly focusing on technology that has advanced into the clinic and those approaches that are broadly applicable to structurally diverse alcohol-containing payloads.
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