Metabolic Profiling: Disease and Xenobiotics
Multivariate analysis of the multi-component analytical profiles of carefully collected biofluid and/or tissue biopsy specimens can provide a 'fingerprint' of their biomolecular/metabolic status. Therefore, if applied correctly, valuable information regarding disease indicators, disease strata and sub-strata and disease activities can be obtained.
This exemplary new book highlights applications of these techniques in the areas of drug therapy and toxicology, cancer, obesity and diabetes, as well as outlining applications to cardiovascular, infectious, inflammatory and oral diseases in detail. The book gives particular reference to cautionary measures that must be applied to the diagnosis and classification of these conditions or physiological criteria. Comprehensively covering a wide range of topics, of particular interest is the focus on experimental design and 'rights and wrongs' of the techniques commonly applied by researchers, and the very recent development of powerful 'Pattern Recognition' techniques.
The book provides a detailed introduction to the area, applications and common pitfalls of the techniques discussed before moving into detailed coverage of specific disease areas, each highlighted in individual chapters. This title will provide an invaluable resource to Medicinal chemists, Biochemists and toxicologists working in industry and academia.
Metabolic Profiling: Disease and Xenobiotics, The Royal Society of Chemistry, 2014.
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Table of contents
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CHAPTER 1: Introduction to the Applications of Chemometric Techniques in ‘Omics’ Research: Common Pitfalls, Misconceptions and ‘Rights and Wrongs’p1-34ByMartin GrootveldMartin GrootveldLeicester School of Pharmacy, Faculty of Health and Life Sciences, De Montfort UniversityThe GatewayLeicesterLE1 9BHUK[email protected]Search for other works by this author on:
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CHAPTER 2: Experimental Design: Sample Collection, Sample Size, Power Calculations, Essential Assumptions and Univariate Approaches to Metabolomics Analysisp35-73ByMartin Grootveld;Martin GrootveldLeicester School of Pharmacy, Faculty of Health and Life Sciences, De Montfort UniversityThe Gateway, LeicesterLE1 9BHUK[email protected]Search for other works by this author on:Victor Ruiz RodadoVictor Ruiz RodadoLeicester School of Pharmacy, Faculty of Health and Life Sciences, De Montfort UniversityThe Gateway, LeicesterLE1 9BHUK[email protected]Search for other works by this author on:
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CHAPTER 3: Recent Developments in Exploratory Data Analysis and Pattern Recognition Techniquesp74-116ByMartin GrootveldMartin GrootveldLeicester School of Pharmacy, Faculty of Health and Life Sciences, De Montfort UniversityThe GatewayLeicesterLE1 9YHUK[email protected]Search for other works by this author on:
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CHAPTER 4: Analysis of High-dimensional Data from Designed Metabolomics Studiesp117-136ByJohan A. Westerhuis;Johan A. WesterhuisBiosystems Data Analysis, Swammerdam Institute for Life Sciences, University of AmsterdamThe NetherlandsCentre for Business, Mathematics & Informatics, North West UniversityPotchefstroomSouth Africa[email protected]Search for other works by this author on:Ewoud J. J. van Velzen;Ewoud J. J. van VelzenBiosystems Data Analysis, Swammerdam Institute for Life Sciences, University of AmsterdamThe NetherlandsUnilever Research and DevelopmentVlaardingenThe NetherlandsSearch for other works by this author on:Jeroen J. Jansen;Jeroen J. JansenBiosystems Data Analysis, Swammerdam Institute for Life Sciences, University of AmsterdamThe NetherlandsSearch for other works by this author on:Huub C. J. Hoefsloot;Huub C. J. HoefslootBiosystems Data Analysis, Swammerdam Institute for Life Sciences, University of AmsterdamThe NetherlandsSearch for other works by this author on:Age K. SmildeAge K. SmildeBiosystems Data Analysis, Swammerdam Institute for Life Sciences, University of AmsterdamThe NetherlandsSearch for other works by this author on:
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CHAPTER 5: Current Trends in Multivariate Biomarker Discoveryp137-161ByDarius M. DziudaDarius M. DziudaDepartment of Mathematical Sciences, Central Connecticut State UniversityNew Britain, CTUSA[email protected]Search for other works by this author on:
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CHAPTER 6: Discovery-based Studies of Mammalian Metabolomes with the Application of Mass Spectrometry Platformsp162-198ByWarwick B. Dunn;Warwick B. DunnCentre for Advanced Discovery & Experimental Therapeutics (CADET), Central Manchester NHS Foundation Trust and School of Biomedicine, University of Manchester, Manchester Academic Health Sciences CentreYork Place, Oxford RoadManchesterM13 9WLUK[email protected]Manchester Centre for Integrative Systems Biology and School of Chemistry, Manchester Interdisciplinary Biocentre, University of Manchester131 Princess StreetManchesterM1 7DNUKSearch for other works by this author on:Catherine L. Winder;Catherine L. WinderManchester Centre for Integrative Systems Biology and School of Chemistry, Manchester Interdisciplinary Biocentre, University of Manchester131 Princess StreetManchesterM1 7DNUKSearch for other works by this author on:Kathleen M. CarrollKathleen M. CarrollManchester Centre for Integrative Systems Biology and School of Chemistry, Manchester Interdisciplinary Biocentre, University of Manchester131 Princess StreetManchesterM1 7DNUKSearch for other works by this author on:
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Chapter 7: Recent Advances in the Multivariate Chemometric Analysis of Cancer Metabolic Profilingp199-219ByKenichi Yoshida;Kenichi YoshidaDepartment of Life Sciences, Meiji University1-1-1 HigashimitaTama-kuKawasakiKanagawa214-8571Japan[email protected]Search for other works by this author on:Martin GrootveldMartin GrootveldLeicester School of Pharmacy, De Montfort UniversityThe GatewayLeicester LE1 9BHUnited Kingdom[email protected]Search for other works by this author on:
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CHAPTER 8: Group-specific Internal Standard Technology (GSIST) for Mass Spectrometry-based Metabolite Profilingp220-254ByJiri AdamecJiri AdamecDepartment of Biochemistry and Redox Biology Center, University of Nebraska – LincolnLincolnNE 68588USA[email protected]Search for other works by this author on:
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CHAPTER 9: 18O-assisted 31P NMR and Mass Spectrometry for Phosphometabolomic Fingerprinting and Metabolic Monitoringp255-286ByEmirhan Nemutlu;Emirhan NemutluDivision of Cardiovascular Diseases, Departments of Medicine, Molecular Pharmacology and Experimental Therapeutics, Mayo ClinicRochester, MNUSA[email protected]Department of Analytical Chemistry, Faculty of Pharmacy, University of HacettepeAnkaraTurkey[email protected]Search for other works by this author on:Song Zhang;Song ZhangDivision of Cardiovascular Diseases, Departments of Medicine, Molecular Pharmacology and Experimental Therapeutics, Mayo ClinicRochester, MNUSA[email protected]Search for other works by this author on:Andre Terzic;Andre TerzicDivision of Cardiovascular Diseases, Departments of Medicine, Molecular Pharmacology and Experimental Therapeutics, Mayo ClinicRochester, MNUSA[email protected]Search for other works by this author on:Petras DzejaPetras DzejaDivision of Cardiovascular Diseases, Departments of Medicine, Molecular Pharmacology and Experimental Therapeutics, Mayo ClinicRochester, MNUSA[email protected]Search for other works by this author on:
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CHAPTER 10: Investigations of the Mechanisms of Action of Oral Healthcare Products using 1H NMR-based Chemometric Techniquesp287-322ByC. J. L. Silwood;C. J. L. SilwoodInstitute for Materials Research and Innovation, University of BoltonDeane RoadBoltonBL3 5ABUK[email protected]Search for other works by this author on:Martin GrootveldMartin GrootveldLeicester School of Pharmacy, De Montfort UniversityThe Gateway, LeicesterLE1 9BHUK[email protected]Search for other works by this author on:
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Chapter 11: Metabolomics Investigations of Drug-induced Hepatotoxicityp323-356
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Chapter 12: Chemogenomicsp357-378ByVirendra S. Gomase;Virendra S. GomaseDepartment of Bioinformatics, Padmashree Dr. D. Y. Patil UniversityPlot No-50, Sector-15CBD Belapur, Navi Mumbai400614 (MS)India[email protected]Search for other works by this author on:Akshay N. Parundekar;Akshay N. ParundekarDepartment of Bioinformatics, Padmashree Dr. D. Y. Patil UniversityPlot No-50, Sector-15CBD Belapur, Navi Mumbai400614 (MS)India[email protected]Search for other works by this author on:Archana B. KhadeArchana B. KhadeDepartment of Bioinformatics, Padmashree Dr. D. Y. Patil UniversityPlot No-50, Sector-15CBD Belapur, Navi Mumbai400614 (MS)India[email protected]Search for other works by this author on:
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