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This book is dedicated to the memory of our fathers, Raymond Cox (1927–2013) and Malcolm John Gosling (1947–2011), for their inspiration, love and support.

This book is also dedicated to the exceptional talented individuals of Ciba, Ciba-Giegy and Novartis who worked at the Horsham site (1937–2014) in their tireless pursuit of medicines to alleviate suffering.

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