Ionic Current Detection of DNA Origami Nanostructures with Nanocapillaries Check Access

DNA origami is a powerful technique for the construction of designer nanopores. Nanocapillaries can be used both to detect the translocation of DNA origami structures and to trap the origami to form a hybrid pore by tuning the diameter of the nanopore. The detection of translocations is a potential new tool for assessing the folding quality and aggregation of DNA origami in solution. The formation of a hybrid origami-nanocapillary nanopore represents a novel method for creating hybrid nanopores with high throughput and low cost.