Tandem Mass Spectrometry of Lipids
Chapter 5: Glycerophospholipids
Published:02 Dec 2014
Special Collection: 2014 ebook collection , 2011-2015 analytical chemistry subject collection
2014. "Glycerophospholipids", Tandem Mass Spectrometry of Lipids, Robert C Murphy
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Glycerophospholipids are phosphodiesters of glycerol and an alcohol referred to as the polar headgroup. The two glycerol carbinol groups are typically esterified with long chain fatty acyl groups which impart hydrophobic character to these otherwise polar molecules. The simplest glycerophospholipid is phosphatidic acid which is a monophosphoester of diacylglycerol. The common polar headgroups are choline, ethanolamine, serine, inositol, and glycerol which divide the phospholipids into different classes. This chapter discusses glycerophosphocholine lipids (PC), glycerophosphoethanolamine lipids (PE), phosphatidylserine (PS), phosphatidic acid (PA), phosphatidylinositol (PI), phosphatidylglycerol (PG), bis(acyl-lysophosphatidyl)glycerol (BMP) and cardiolipin.