Chapter 6: Dynamic Kinetic Resolutions Promoted by Thiourea Catalysts

This chapter includes all types of dynamic kinetic resolution promoted by chiral thiourea catalysts, which constitute some of the most widely employed chiral hydrogen-bond–donor catalysts. A number of these stable, tunable and readily available organocatalysts, among which many are derived from cinchona alkaloids, have been successfully applied in the field of dynamic kinetic resolutions. For example, enantioselectivities of up to 98% ee have been reported in different types of reaction, including alcoholytic ring-opening reactions, domino reactions and acetalisations.