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This chapter summarises the International System of Units (SI Units) applicable to the analysis of organic compounds and drug molecules. By using practical examples and problem-solving exercises, units of measurements including length, mass, temperature, time, volume, and density, and calculations based on moles (e.g. mole fraction, mole percentage, molality, molarity, and normality) are included. The solubility of organic compounds is reviewed by defining parameters such as solutes, solvents, solvation and dissolution, and other physical property measurements such as boiling point, density, and melting point. Underpinning topics outlined in the various chapters, acid–base properties with definitions, principles and applications in chemical measurements, and common reactions of organic compounds are scrutinised.

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