Dienamine Catalysis for Organic Synthesis
CHAPTER 11: Tetraenamine-catalyzed Stereoselective Cycloadditions of Polyunsaturated Carbonyl Compounds
Published:02 Mar 2018
Special Collection: 2018 ebook collectionSeries: Catalysis Series
Indresh Kumar, Dhevalapally B. Ramachary, 2018. "Tetraenamine-catalyzed Stereoselective Cycloadditions of Polyunsaturated Carbonyl Compounds", Dienamine Catalysis for Organic Synthesis, Kengadarane Anebouselvy, Dhevalapally B Ramachary, Indresh Kumar
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The recent progress in the ability of amine catalysis to functionalize polyunsaturated carbonyl compounds was made possible by highest occupied molecular orbital (HOMO)-raising or lowest unoccupied molecular orbital (LUMO)-lowering activations. In this context, the HOMO-raising dienamine and trienamine activation strategy has been explored extensively for the functionalization of polyconjugated carbonyl compounds at remote positions. This concept was recently stretched further to tetraenamine catalysis, a new activation strategy for amine-catalyzed HOMO-activation. The concept of tetraenamine catalysis is quite modern and only a few examples of the asymmetric Diels–Alder reaction are known so far. In this chapter, we will discuss the very first breakthroughs in the direction of tetraenamine catalysis.