12: Applications of Biocatalytic Retrosynthesis

The final chapter concludes the book by giving readers the opportunity to test their understanding of applying biocatalysis in organic synthesis and in particular gain experience in disconnecting target molecules based on the principles of biocatalytic retrosynthesis. 25 worked examples, of increasing difficulty, are provided to enable students of biocatalysis to develop their skills and apply their knowledge. As the target molecules become more complex, it becomes increasingly challenging to identify the ‘hidden’ disconnections that lead to the application of a biocatalyst in the key step. Each example is accompanied by a solution and reference, such that the readers can understand the thinking behind the synthesis, and also read-up in greater detail at their leisure.