The third chapter of the book includes the advances achieved in enantioselective nickel-catalysed cross-coupling reactions since 2004, well demonstrating that nickel is emerging as an extraordinarily versatile catalyst for asymmetric cross-coupling reactions of a wide range of coupling partners. In particular, an impressive number of highly efficient asymmetric versions of the Negishi reaction involving a range of activated and non-activated secondary halides have been successfully developed under catalysis with various chiral nickel complexes, providing excellent enantioselectivities in almost all cases, which has considerably expanded the scope of these C–C bond-formation methodologies. In addition, the first enantioselective versions of the Kumada, Hiyama, and Suzuki reactions were recently achieved with excellent enantioselectivities. Important advances have also been made in the area of enantioselective nickel-catalysed reductive coupling reactions in the last decade.