| Reagents and Solvents | |
|---|---|
| BOP | 1-Benzotriazolyloxy-tris-dimethylamino-phosphonium hexafluorophosphate |
| CDI | Carbonyldiimidazole |
| DBU | Diazabicyclo[5.4.0]-undec-7-ene |
| DCCI | Dicyclohexylcarbodiimide (also DCC) |
| DCHU | Dicyclohexylurea (also DCU) |
| DCM | Dichloromethane |
| DEAD | Diethyl azodicarboxylate (DMAD=the dimethyl analogue) |
| DIPCI | Diisopropylcarbodiimide (also DIC) |
| DIPEA | Diisopropylethylamine (also DIEA) |
| DMA | Dimethylacetamide |
| DMAP | 4-Dimethylaminopyridine |
| DMF | Dimethylformamide |
| DMS | Dimethylsulphide |
| DMSO | Dimethylsulphoxide |
| DPAA | Diphenylphosphoryl azide |
| EEDQ | 2-Ethoxy-1-ethoxycarbonyl-1,2-dihydroquinoline |
| HATU | This is the acronym for the ‘uronium’ coupling reagent derived from HOAt, which was originally thought to have the structure 8, the Hexafluorophosphate salt of the O-(7-Azabenzotriazol-lyl)-Tetramethyl Uronium cation.  In fact this reagent has the isomeric N-oxide structure 9 in the crystalline state, the unwieldy correct name of which does not conform logically with the acronym, but the acronym continues in use.  Similarly, the corresponding reagent derived from HOBt has the firmly attached label HBTU (the tetrafluoroborate salt is also used: TBTU), despite the fact that it is not actually a uronium salt. |
| HMP | Hexamethylphosphoric triamide (also HMPA, HMPTA) |
| HOAt | 1-Hydroxy-7-azabenzotriazole |
| HOBt | 1-Hydroxybenzotriazole |
| HOCt | 1-Hydroxy-4-ethoxycarbonyl-1,2,3-triazole |
| NDMBA | N,N′-Dimethylbarbituric acid |
| NMM | N-Methylmorpholine |
| PAM | Phenylacetamidomethyl resin |
| PEG | Polyethylene glycol |
| PtBOP | 1-Benzotriazolyloxy-tris-pyrrolidinophosphonium hexafluorophosphate |
| SDS | Sodium dodecyl sulphate |
| TBAF | Tetrabutylammonium fluoride |
| TBTU | See remarks under HATU above |
| TEA | Triethylamine |
| TFA | Trifluoroacetic acid |
| TFE | Trifluoroethanol |
| TFMSA | Trifluoromethanesulphonic acid |
| THF | Tetrahydrofuran |
| WSCI | Water soluble carbodiimide: 1-ethyl-3-(3′-dimethylaminopropyl)-carbodiimide hydrochloride (also EDC) |
| Reagents and Solvents | |
|---|---|
| BOP | 1-Benzotriazolyloxy-tris-dimethylamino-phosphonium hexafluorophosphate |
| CDI | Carbonyldiimidazole |
| DBU | Diazabicyclo[5.4.0]-undec-7-ene |
| DCCI | Dicyclohexylcarbodiimide (also DCC) |
| DCHU | Dicyclohexylurea (also DCU) |
| DCM | Dichloromethane |
| DEAD | Diethyl azodicarboxylate (DMAD=the dimethyl analogue) |
| DIPCI | Diisopropylcarbodiimide (also DIC) |
| DIPEA | Diisopropylethylamine (also DIEA) |
| DMA | Dimethylacetamide |
| DMAP | 4-Dimethylaminopyridine |
| DMF | Dimethylformamide |
| DMS | Dimethylsulphide |
| DMSO | Dimethylsulphoxide |
| DPAA | Diphenylphosphoryl azide |
| EEDQ | 2-Ethoxy-1-ethoxycarbonyl-1,2-dihydroquinoline |
| HATU | This is the acronym for the ‘uronium’ coupling reagent derived from HOAt, which was originally thought to have the structure 8, the Hexafluorophosphate salt of the O-(7-Azabenzotriazol-lyl)-Tetramethyl Uronium cation. In fact this reagent has the isomeric N-oxide structure 9 in the crystalline state, the unwieldy correct name of which does not conform logically with the acronym, but the acronym continues in use. Similarly, the corresponding reagent derived from HOBt has the firmly attached label HBTU (the tetrafluoroborate salt is also used: TBTU), despite the fact that it is not actually a uronium salt. |
| HMP | Hexamethylphosphoric triamide (also HMPA, HMPTA) |
| HOAt | 1-Hydroxy-7-azabenzotriazole |
| HOBt | 1-Hydroxybenzotriazole |
| HOCt | 1-Hydroxy-4-ethoxycarbonyl-1,2,3-triazole |
| NDMBA | N,N′-Dimethylbarbituric acid |
| NMM | N-Methylmorpholine |
| PAM | Phenylacetamidomethyl resin |
| PEG | Polyethylene glycol |
| PtBOP | 1-Benzotriazolyloxy-tris-pyrrolidinophosphonium hexafluorophosphate |
| SDS | Sodium dodecyl sulphate |
| TBAF | Tetrabutylammonium fluoride |
| TBTU | See remarks under HATU above |
| TEA | Triethylamine |
| TFA | Trifluoroacetic acid |
| TFE | Trifluoroethanol |
| TFMSA | Trifluoromethanesulphonic acid |
| THF | Tetrahydrofuran |
| WSCI | Water soluble carbodiimide: 1-ethyl-3-(3′-dimethylaminopropyl)-carbodiimide hydrochloride (also EDC) |