Table 1.1

Overview of the type of biochemical and immuno-assays conducted by a clinical biochemistry laboratory on an annual basis (source: St. Michael’s Hospital, Toronto, Canada).

Type of TestNumber performed (per year)
Acetone, quantitative* 448 
Albumin, quantitative* 125 360 
Alcohol, ethyl-quantitative* 5010 
Alcohol, fractionation and quantification* 5889 
Amylase* 21477 
Barbiturates, quantitative* 13 898 
Barbiturates, fractionation and quantification (serum) – includes other drugs requiring similar methodology (e.g. tricyclic antidepressants)* 704 
Bilirubin, total* 72 000 
Bilirubin, conjugated* 22 545 
pH* 20 
pCO2, pO2 and pH in combination* 62 757 
Carbamazepine, quantitative (Tegretol)* 504 
Chlordiazepoxide, quantitative (Librium)* 10 
Calcium* 91 723 
Calcium ionized* 9676 
Catecholamines, fractionated* 2485 
Chloride* 227 057 
Cholesterol, total* 34 663 
Acetaminophen* 5036 
Carboxyhemoglobin* 
CO2 content, CO2 combining power, bicarbonate (measured not calculated)* 219 783 
Creatine phosphokinase* 63 914 
Creatinine* 257 139 
Creatinine clearance* 4884 
Target drug testing, urine, qualitative or quantitative* 37 691 
Diazepam, quantitative (Valium, Vivol)* 37 
Drugs of abuse screen, urine* 48 
Broad spectrum toxicology screen, urine – includes confirmatory testing* 7399 
Electrophoresis, serum – including total protein 7556 
Electrophoresis, other than serum – including total protein* 599 
Glycosylated hemoglobin – Hgb A1* 19 394 
Flurzepam, quantitative (Dalmane)* 
Glucose tolerance test in pregnancy* 2694 
Glucose tolerance test* 973 
Gamma glutamyl transpeptidase* 7705 
Glucose, quantitative (not by dipstick)* 188 863 
Glucose, semiquantitative (dipstick if read with reflectance meter)* 46 538 
High density lipoprotein cholesterol* 32 179 
5H1AA quantification – U* 1554 
Hemoglobin A2 by chromatography* 2030 
Iron, total – with iron binding capacity and percent saturation* 21 054 
Lactic acid (lactate)* 13 733 
Lactic dehydrogenase (L.D.H), total* 19 245 
Lipase 1475 
Lipoprotein, electrophoresis* 
Lipoprotein, ultracentrifugation* 499 
Lithium* 866 
Lidocaine* 86 
Methotrexate (amethopterin)* 115 
N-acetylprocainamide* 74 
Magnesium* 84 408 
Metanephrines, total – U* 2712 
Methemoglobin* 77 
Myoglobin, quantitative – U* 176 
Occult blood* 4293 
Osmolality (osmolarity)* 10 044 
Oxalic acid (Oxalate) – U* 3104 
Phenothiazines, quantitive – U* 69 
Phosphatase, alkaline* 82 037 
Phosphatase, alkaline fractionation* 62 
Phosphorus (inorganic phosphate)* 86 956 
Plasma hemoglobin* 44 
Potassium* 235 045 
Protein, total* 110 937 
Primidone, quantitative (Mysoline)* 420 
Procainamide* 71 
Quinidine* 18 
Salicylate, quantitative* 4875 
SGOT (AST)* 88 095 
SGPT (ALT)* 80 304 
Sodium* 237 209 
Thiocyanates* 15 
Triglycerides* 33426 
Urea Nitrogen (B.U.N.)* 201 706 
Uric Acid (urate)* 23 038 
Urinalysis, routine chemical (any of S.G., pH, protein, sugar, hemoglobin, ketones, urobilinogen, bilirubin, leukocyte esterase, nitrite)* 37 534 
Urinalysis microscopic examination of centrifuged specimen* 11 497 
Valproic acid (valproate)* 1154 
VMA, Vanillylmandelic acid (Vanillylmandelate)* 1212 
Biochemical assays not included above* 7844 
Prostate specific antigen (PSA), total 1063 
Alpha Glycoprotein Subunit 179 
Amylase isoenzymes 535 
Apolipoproteins A and B 12 478 
FK506 (Tacrolimus) 8577 
Lipoprotein (a) 792 
Prostate specific antigen (PSA), total 4258 
Troponin 44 477 
Homocysteine 1585 
Chylomicrons 
Oligoclonal banding 1437 
Citrate 2967 
Sirolimus (Rapamycin) 526 
Natriuretic peptide – Brain (BNP) 3201 
Foetal fibronectin 16 
Bioavailable testosterone 12 886 
Aldosterone* 3059 
Cortisol* 3470 
Aminoglycosides (e.g. Gentamicin, Tobramycin)* 1108 
Androsternedione* 1215 
Digoxin* 1103 
ACTH (andrenocorticotrophic hormone)* 1520 
Folate, in red cells, to include hematocrite and if requested, serum folate* 7710 
Estradiol* 1914 
FSH (pituitary gonadotropins)* 2807 
Growth hormone* 2343 
HCG (human chorionic gonadotropins)* 9848 
Hepatitis associated antigen or antibody immuno-assay ‐ per assay (e.g. hepatitis B surface antigen or antibody, hepatitis B core antibody, hepatitis A antibody)* 11 469 
Aminophylline (Theophylline)* 167 
Anti-DNA* 1822 
Diphenylhydantoin (Phenytoin), quantitative (Dilantin)* 2424 
Insulin* 802 
LH (luteinizing hormone) 3091 
Ferritin* 17 240 
Parathyroid hormone* 7256 
Progesterone* 908 
Prolactin* 3104 
17‐OH Progesterone* 308 
IgE* ‐ not to be billed for RAST test 1131 
T4, free ‐ absolute (includes T‐4 total)* 11 888 
Testosterone 12 767 
TSH (thyroid stimulating hormone)* 30 406 
Phenobarbitone* 363 
Vitamin B12* 10 897 
C-peptide immunoreactivity* 1084 
Dehydroepiandrosterone sulfate (DHEAS)* 664 
25-hydroxy vitamin D* 7703 
T‐3, free* 6350 
Thyroglobulin* 2466 
Alphafetoprotein 942 
Hormone receptors for carcinoma (to include estrogen and/or progesterone assays)* 793 
Total 3 274 901 
Type of TestNumber performed (per year)
Acetone, quantitative* 448 
Albumin, quantitative* 125 360 
Alcohol, ethyl-quantitative* 5010 
Alcohol, fractionation and quantification* 5889 
Amylase* 21477 
Barbiturates, quantitative* 13 898 
Barbiturates, fractionation and quantification (serum) – includes other drugs requiring similar methodology (e.g. tricyclic antidepressants)* 704 
Bilirubin, total* 72 000 
Bilirubin, conjugated* 22 545 
pH* 20 
pCO2, pO2 and pH in combination* 62 757 
Carbamazepine, quantitative (Tegretol)* 504 
Chlordiazepoxide, quantitative (Librium)* 10 
Calcium* 91 723 
Calcium ionized* 9676 
Catecholamines, fractionated* 2485 
Chloride* 227 057 
Cholesterol, total* 34 663 
Acetaminophen* 5036 
Carboxyhemoglobin* 
CO2 content, CO2 combining power, bicarbonate (measured not calculated)* 219 783 
Creatine phosphokinase* 63 914 
Creatinine* 257 139 
Creatinine clearance* 4884 
Target drug testing, urine, qualitative or quantitative* 37 691 
Diazepam, quantitative (Valium, Vivol)* 37 
Drugs of abuse screen, urine* 48 
Broad spectrum toxicology screen, urine – includes confirmatory testing* 7399 
Electrophoresis, serum – including total protein 7556 
Electrophoresis, other than serum – including total protein* 599 
Glycosylated hemoglobin – Hgb A1* 19 394 
Flurzepam, quantitative (Dalmane)* 
Glucose tolerance test in pregnancy* 2694 
Glucose tolerance test* 973 
Gamma glutamyl transpeptidase* 7705 
Glucose, quantitative (not by dipstick)* 188 863 
Glucose, semiquantitative (dipstick if read with reflectance meter)* 46 538 
High density lipoprotein cholesterol* 32 179 
5H1AA quantification – U* 1554 
Hemoglobin A2 by chromatography* 2030 
Iron, total – with iron binding capacity and percent saturation* 21 054 
Lactic acid (lactate)* 13 733 
Lactic dehydrogenase (L.D.H), total* 19 245 
Lipase 1475 
Lipoprotein, electrophoresis* 
Lipoprotein, ultracentrifugation* 499 
Lithium* 866 
Lidocaine* 86 
Methotrexate (amethopterin)* 115 
N-acetylprocainamide* 74 
Magnesium* 84 408 
Metanephrines, total – U* 2712 
Methemoglobin* 77 
Myoglobin, quantitative – U* 176 
Occult blood* 4293 
Osmolality (osmolarity)* 10 044 
Oxalic acid (Oxalate) – U* 3104 
Phenothiazines, quantitive – U* 69 
Phosphatase, alkaline* 82 037 
Phosphatase, alkaline fractionation* 62 
Phosphorus (inorganic phosphate)* 86 956 
Plasma hemoglobin* 44 
Potassium* 235 045 
Protein, total* 110 937 
Primidone, quantitative (Mysoline)* 420 
Procainamide* 71 
Quinidine* 18 
Salicylate, quantitative* 4875 
SGOT (AST)* 88 095 
SGPT (ALT)* 80 304 
Sodium* 237 209 
Thiocyanates* 15 
Triglycerides* 33426 
Urea Nitrogen (B.U.N.)* 201 706 
Uric Acid (urate)* 23 038 
Urinalysis, routine chemical (any of S.G., pH, protein, sugar, hemoglobin, ketones, urobilinogen, bilirubin, leukocyte esterase, nitrite)* 37 534 
Urinalysis microscopic examination of centrifuged specimen* 11 497 
Valproic acid (valproate)* 1154 
VMA, Vanillylmandelic acid (Vanillylmandelate)* 1212 
Biochemical assays not included above* 7844 
Prostate specific antigen (PSA), total 1063 
Alpha Glycoprotein Subunit 179 
Amylase isoenzymes 535 
Apolipoproteins A and B 12 478 
FK506 (Tacrolimus) 8577 
Lipoprotein (a) 792 
Prostate specific antigen (PSA), total 4258 
Troponin 44 477 
Homocysteine 1585 
Chylomicrons 
Oligoclonal banding 1437 
Citrate 2967 
Sirolimus (Rapamycin) 526 
Natriuretic peptide – Brain (BNP) 3201 
Foetal fibronectin 16 
Bioavailable testosterone 12 886 
Aldosterone* 3059 
Cortisol* 3470 
Aminoglycosides (e.g. Gentamicin, Tobramycin)* 1108 
Androsternedione* 1215 
Digoxin* 1103 
ACTH (andrenocorticotrophic hormone)* 1520 
Folate, in red cells, to include hematocrite and if requested, serum folate* 7710 
Estradiol* 1914 
FSH (pituitary gonadotropins)* 2807 
Growth hormone* 2343 
HCG (human chorionic gonadotropins)* 9848 
Hepatitis associated antigen or antibody immuno-assay ‐ per assay (e.g. hepatitis B surface antigen or antibody, hepatitis B core antibody, hepatitis A antibody)* 11 469 
Aminophylline (Theophylline)* 167 
Anti-DNA* 1822 
Diphenylhydantoin (Phenytoin), quantitative (Dilantin)* 2424 
Insulin* 802 
LH (luteinizing hormone) 3091 
Ferritin* 17 240 
Parathyroid hormone* 7256 
Progesterone* 908 
Prolactin* 3104 
17‐OH Progesterone* 308 
IgE* ‐ not to be billed for RAST test 1131 
T4, free ‐ absolute (includes T‐4 total)* 11 888 
Testosterone 12 767 
TSH (thyroid stimulating hormone)* 30 406 
Phenobarbitone* 363 
Vitamin B12* 10 897 
C-peptide immunoreactivity* 1084 
Dehydroepiandrosterone sulfate (DHEAS)* 664 
25-hydroxy vitamin D* 7703 
T‐3, free* 6350 
Thyroglobulin* 2466 
Alphafetoprotein 942 
Hormone receptors for carcinoma (to include estrogen and/or progesterone assays)* 793 
Total 3 274 901 
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