Drug delivery of iTSL-topotecan and efficacy upon heating; (a) and (b) show the low magnification (20×), and (c) and (d) show the high magnification (100×) of tumour sections (z-stack) imaged by confocal microscopy. The topotecan gives the green fluorescence while the nucleus of the cells is counterstained by DAPI (blue). Reprinted from ref. 74. Copyright (2015) American Chemical Society.