Representative pathways integrating transcriptomics and metabolomics results corresponding to (A) transfer RNA (tRNA) charging, (B) Glutathione redox reactions I, (C) Carnitine shuttle and fatty acid β-oxidation and (D) Pyrimidine ribonucleotides interconversion. Rhombus-shaped nodes represent the expression of genes and rectangular nodes represent metabolites. Downregulated- and upregulated components are shown on a dark grey or grey background, respectively. Reproduced from ref. 87 with permission from Elsevier, Copyright 2019.