Properties of band-selective pulse shapes used in BEST and SOFAST experiments. (a) The amplitude-modulated time-domain profiles of PC9,21 EBURP-2,17 REBURP,17 and Q319 are plotted together with the corresponding binary replacement schemes obtained from numerical simulations.22 Chemical shift and heteronuclear coupling evolution during the pulse shape is represented by open squares, while the time during which the actual spin rotation is occurring is represented by a black square. In addition the corresponding frequency-response of the spins is shown for each pulse shape. The binary replacement schemes make it straightforward to account for spin evolution in the basic BEST-type pulse sequence elements: (b) INEPT, (c) sensitivity-enhanced reverse INEPT (SE REVINEPT), and (d) single-transition-to-single-transition polarization transfer (ST2-PT).