Royal Society of Chemistry

Scheme 11

Ester light fluorous tag for the synthesis of a sulfated glycosaminoglycan hexamer.72,73 Reagents and conditions MP = p-methoxyphenyl (a) Et3N, DMAP, DCM, 0 °C, 81%; (b) TBSOTf, DCM, 0 °C; (c) NH2NH2·H2O, Py-AcOH, DCM; (d) TBSOTf, DCM, room temperature; (e) (HF)n·Py, THF, 0 °C; SO3·Me3N, DMF, 100 °C, MW heating, 56%.

Ester light fluorous tag for the synthesis of a sulfated glycosaminoglycan hexamer.^72,73 Reagents and conditions MP = p-methoxyphenyl (a) Et₃N, DMAP, DCM, 0 °C, 81%; (b) TBSOTf, DCM, 0 °C; (c) NH₂NH₂·H₂O, Py-AcOH, DCM; (d) TBSOTf, DCM, room temperature; (e) (HF)n·Py, THF, 0 °C; SO₃·Me₃N, DMF, 100 °C, MW heating, 56%.

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